منابع مشابه
Maintenance of normal, metaplastic, and dysplastic states of adult human bronchial mucosa in organ culture.
SUMMARY Bronchial mucosa was obtained from 10 patients undergoing lobectomy (8 for squamous bronchogenic carcinoma) and from 13 patients examined by bronchoscopy. Randomly chosen mucosal patches were incubated with tritiated thymidine and fixed as fresh samples, while others were labeled and fixed after 5 to 15 days of maintenance in organculture.Histological andautoradiographic observations in...
متن کاملOrgan culture of gastrointestinal mucosa--a technique for the study of the human gastrointestinal tract.
Organ culture developed about 50 years ago, mainly for the study of morphogenesis in embryological tissue. Fell and co-workers in Cambridge studied many embryological events in vitro (Fell, 1940), and organ culture came to be defined as that type of culture where complete rudiments or fragments of organs were cultivated with a minimum of outgrowth and enlarged as a whole (Fell, 1953; Parker, 19...
متن کاملPossible phagocytosis by keratinocytes: ultrastructural evidence from the study of human oral mucosa in organ culture.
Surgical samples of human oral mucosa undergo striking transformations within 24 hr, when maintained in organ culture, at 37”C, on fibrin foam mats, with 5 per cent CO2 in air as the atmosphere. These transformations include disorganization of the tonofibrillar apparatus, reduction or loss of desmosomes, and loss of the intercellular relationships characteristic of stratified squamous epitheliu...
متن کاملInhibition of prostaglandin synthetase in human rectal mucosa.
Miniaturised methods have been used to construct dose-response curves for the effects of inhibitory drugs on prostaglandin synthesis using individual rectal biopsies obtained from patients with ulcerative colitis. The potency of different drugs has been compared. Sulphasalazine, 5 amino salicylic acid (5-ASA) and N-acetyl 5-ASA inhibited prostaglandin synthesis at high concentration, but sulpha...
متن کاملHuman Cancer Biology The Rectal Cancer microRNAome –microRNA Expression in Rectal Cancer and Matched Normal Mucosa
Purpose: miRNAs play a prominent role in a variety of physiologic and pathologic biologic processes, including cancer. For rectal cancers, only limited data are available on miRNA expression profiles, whereas the underlying genomic and transcriptomic aberrations have been firmly established. We therefore, aimed to comprehensively map the miRNA expression patterns of this disease. Experimental D...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1973
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(73)80159-3